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Graf and Kastin's seminal review identified a U-shaped dose-response curve for DSIP — both dose and timing of administration affect whether the peptide promotes sleep, modulates stress hormones, or influences circadian patterns (Graf & Kastin, 1984)

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In human subjects, several studies suggest that high selenium supplementation increases the risk of type 2 diabetes [103, 104], and, in mouse models, increased expression of selenoproteins as well as selenoprotein deficiency was also correlated with metabolic dysregulation [105]