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Remember, MTHFR is critical for the formation of 5-Me-THF (aka, L-methylfolate, L-methyl-THF) which is involved in the methylation of homocysteine and its conversion to methionine

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However, this does not eliminate long-term hepatotoxic risk — alcohol-related liver disease develops through cumulative damage from chronic consumption, and no supplement negates the dose-response relationship between alcohol intake and cirrhosis risk