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Reactivation of oxidized PTP enzymes is achieved through reduction by TXN1 [199], and we therefore envisage that in Nrf2 −/− cells the combined effects of higher ROS levels coupled with diminished TXN1 activity (as a consequence of lower expression of TXNRD1 and SRXN1) will heighten signaling through the insulin, EGFR, and PDGFR pathways