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Mean blood pressure (MBP, mmHg) was monitored continuously by a Haemosys computerized dataacquisition system through the femoral catheter using a pressure transducer connected to an electromanometer (Experimetria Ltd., Budapest, Hungary)

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O-GlcNAcylation further stabilizes ACSL4, thereby promoting ferroptosis, indicating that hyperglycemia can directly activate this cell death pathway ( − (xCT) and consuming GSH ( In animal models, including db/db mice, streptozotocin (STZ)-induced diabetic models, and non-obese diabetic (NOD) mice, renal tissues show increased iron content, elevated levels of MDA and ACSL4 , and reduced GPX4 expression, which are the signature features of ferroptosis ( CPT1A )-dependent lipid metabolism (Zhang et al., 2024a)