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Although Compounds 1.65 and 1.71 lost efficacy in a major detoxification process of GSH by being unable to interact with the GST enzyme, this did not indicate a loss for all detoxification pathways

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This process must have taken a substantial part of evolution, and the process of melanomagenesis is, according to our latest suggestion, the step back not only in ontogenesis but also in phylogenesis (113)

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