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Additionally, when HEK293 cells are cotransfected with MC3R and a GHSR1a mutant showing impaired or absent constitutive activity, heterodimerization still occurs but amplification of α-MSH-induced cAMP accumulation is lost, suggesting that the twofold increase in cAMP accumulation depends on GHSR1a basal activity (Rediger et al., 2011)

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MicroRNA-34a: a potential therapeutic target in human cancer