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GSH's free thiol (pKa ~9) acts as a reductant: glutathione peroxidase uses two GSH molecules to reduce H₂O₂ or lipid peroxides (producing GSSG and water/alcohol), and NADPH-dependent glutathione reductase regenerates the reduced form

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Triiodothyronine (T3) and L-thyroxine (T4) diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNA