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Interestingly, IR-deficient chondrocytes had increased IGF-1R levels and were more responsive to IGF-1 consistent with the notion that IGF-1/IGF-1R may compensate, at least in part, for loss of IR signaling

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Conclusion In summary, synaptic transmission is the main procedure for information transmission between neurons and/or other cells in the central nervous system and intact synaptic function is fundamental for almost all the nervous functions, including consciousness, memory and cognition