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Concierge-medicine write-ups that describe pairing the two peptides openly concede the protocols are built on mechanistic reasoning and separate animal studies, not on co-administration trials [4][5]

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An average weight loss of -8.1 kg and -10.2 kg was attained at the end of 56 weeks with phentermine 7·5 mg plus topiramate 46·0 mg, and phentermine 15·0 mg plus topiramate 92·0 mg, respectively