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Also, adjuvant 20 mg/day melatonin treatment following resection of non-small cell lung cancer (NSCLC) increased five-year disease-free survival in patients with late-stage disease [78] , reduced the expression of miR-210 and CD44 in squamous cell carcinoma of the oral cavity [78] , and counteracted the dysfunction in the inhibitory pain modulatory system and improved pain perception measures and neuroplasticity state in women with breast cancer [75]