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This is in contrast with the claim that vitamins at mega dose could act as curative agents in some chronic inflammatory or cardiovascular diseases.[29] It seems that the consumption of vitamins in mega doses brings the risk of complications for the subjects as the lack of weight gain in animals treated with mega doses of four vitamins compared to the normal dose in this study.[29] Unlike the results of macroscopic and microscopic evaluation, biochemical results showed that all of the treatment groups including the group which received mega dose of vitamin B6 were able to reduce MPO activity and MDA level significantly compared to the control group