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Supplementary Material Abbreviations Used ATP adenosine triphosphate cAMP cyclic adenosine monophosphate Cat catalase CO 2 carbon dioxide CVD cardiovascular disease ECs endothelial cells eNOS endothelial nitric oxide synthase EPO erythropoietin ESA erythropoiesis-stimulating agent FAD flavin adenine dinucleotide G6PDH glucose-6-phosphate dehydrogenase GPx glutathione peroxidase Gpx4 glutathione peroxidase 4 GRx glutaredoxin GSH glutathione GSSG glutathione disulfide Hb hemoglobin KO knockout MCH mean corpuscular hemoglobin metHb methemoglobin NADH nicotinamide adenine dinucleotide NADPH nicotinamide adenine dinucleotide phosphate NO nitric oxide NOS nitric oxide synthase Nrf2 nuclear factor E2-related factor 2 PLT platelet PMRS plasma membrane redox system Prx2 peroxiredoxin 2 PS phosphatidylserine RBC red blood cell ROS reactive oxygen species SCD sickle cell disease SOD1 superoxide dismutase 1 Trsp tRNA[Sec] Trx thioredoxin VSMC vascular smooth muscle cell Acknowledgments The authors are grateful to the German Research Council (DFG, P9-International Research Training Group 1902 to M.K., M.M.C.K

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TABLE 1 Posological regimens and experimental models of representative natural metabolites used in osteogenesis–angiogenesis studies