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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity — a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

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Health and social care professionals providing NHS-commissioned services Commissioners of services Laboratories People with confirmed or suspected vitamin B12 deficiency, their families and carers Guideline development process How we develop NICE guidelines Your responsibility The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available