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Studies have shown that high doses of ginseng (15 g/d) will lead to ginseng abuse syndrome (GAS), the specific performance is as follows (Siegel, 1979): ①Nervous system: headache, dizziness, fever, restlessness, easy to wake up, insomnia, sweating, euphoria, mania, confusion, cerebral arteritis, mydriasis

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However, one study (Payabvash et al., 2006) showed that a major part of hepatic GSH depletion during endotoxemia is a fall in GCL activity, which as associated with a fall in GCLC mRNA level

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