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Linderstrom-Lang & Schellman, 1959) we can specify four general levels of protein structure: - primary structure - secondary structure - tertiary structure - quaternary structure In this hierarchy primary structure is defined as the number and sequence of amino acid residues linked together by peptide bonds, from N-terminus to C-terminus

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Multiple studies, opinions, and guidelines have suggested melatonin as primary therapy for improved health and sleep of shift workers [69,70,71]