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These are not only damaging, but they can also single-handedly deplete glutathione, creating an imbalance between Phase 1 and Phase 2 (see below) activity.7 Toxic reactions can occur due to the buildup of reactive intermediate forms resulting from phase 1 detoxification, so further work needs to be done to process and eliminate toxins

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doi: 10.3389/fnbeh.2017.00081