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Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice

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The importance of a finely tuned redox balance required for proper HPA-axis function is further stressed in animal experiments, in which antioxidant treatment abolished the increased HPA-axis activity observed following chronic stress, but also promoted a hyperactivation of the HPA-axis activity in non-stressed animals [37]