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The proteins were embedded in a box of OPC water molecules (minimum distance of 12 Å from the solute to the boundaries of the box) and the net charge of the system was set to zero by neutralization with Cl-ions using the program tLEaP included in AmberTools21 ( 60

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Intramuscular B12 Injections By injecting vitamin B12 directly into muscle tissue, intramuscular B12 injections achieve the desired results