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Diabetes 12 , 1179551419844521 (2019)

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Compared with full‐length TB‐500, the fragment shares the same peptide sequence (LKKTETQ) but lacks an aldehyde group on the leucine residue, a difference that reduces its molecular weight (889.0 vs 846.97 g/mol) and is proposed to increase stability, prolong half‐life, and reduce off‐target interactions