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• Gene-Expression-Mediated Persistence: Khavinson's pharmacology framework attributes this durability to transcriptional change: short peptides were observed to produce changes in gene expression, so the peptide acts as a transient trigger for a self-sustaining cellular program rather than a continuously present agonist (PMID 12374906)
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Shortage of vitamin B12 can also result in pernicious anemia, which may be due to impaired absorption of vitamin B12 caused by a lack of intrinsic factor—a substance necessary for the absorption of vitamin B12 in the intestines
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