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Cagrilintide Phase 2 monotherapy (Lau et al., Lancet 2021) reported about 10.8% weight loss at 26 weeks at 4.5 mg

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Trial dose range: 1–12mg, once weekly, subcutaneous Standard escalation: 2mg → +2mg every 4 weeks → 12mg (~20 weeks) Pharmacokinetics: half-life ~6 days