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True as this may be, chronic FOXO4 reduction is not advisable as FOXOs play a role in DNA-damage repair and Foxo4−/− mice are susceptible to acute damage(Zhou et al., 2009)

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Sjögren et al., 1999), which impacts numerous systems with wide-ranging effects, like nervous system, reproductive system, muscular system, skeletal system, and immune system (Lu et al., 2019)