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Detection of mRNA and protein levels showed that KD or ketone bodies can improve mitochondrial biogenesis and bioenergetics through the peroxisome proliferator-activated receptor γ-coactivator-1α – sirtuin 3 – uncoupling proteins 2 axis, and uncoupling proteins upregulated by mitochondrial respiration can reduce the production of ROS and oxidative stress (129, 130)
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