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These effects were mediated by an increase in phosphorylation of mTOR and/or its downstream substrates, p70-S6 kinase (S6K) and the Eukaryotic translation initiation factor 4E-binding protein-1 (4E-BP1) [21]

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[DOI] [PubMed] [Google Scholar] 17.Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G