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Wambier Journal JAAD International (Journal of the American Academy of Dermatology) Year 2025 Study type Retrospective clinical study with blinded evaluation and AI-assisted assessment Sample size 7 male patients, ages 28–55, Norwood-Hamilton III–IV Full paper PubMed — PMID 40225275 · Full text (PMC) · DOI: 10.1016/j.jdin.2025.01.012 Reviewed by: Esther Bodde, MD — Cosmetic & Plastic Surgeon Why This Research Matters This 2025 study is one of the first to combine three active ingredients — minoxidil, dutasteride, and copper peptides — delivered directly into the scalp using a medical-grade tattooing technique

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THSD4 has been shown to promote hair growth by enhancing the interaction between DP and epithelial cells via the SDC4-THSD4-CXCL1 signaling axis [141], underscoring the concept that improving the interaction between DP and HM can promote hair regrowth