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Population pharmacokinetic modeling estimates Saphnelo’s overall clearance rate at about 0.193 L/day , supporting its prolonged action and effects in the body

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¹⁶ Over-loss and muscle — the pooled SURMOUNT analysis shows the tail changing with time: BMI below 22 reached about 8.3% by week 72 and 14.6% in the longer 88-week SURMOUNT-4 instrument, while BMI below 18.5 remained uncommon, roughly 0.3–1.5%