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[18] A 2018 systematic review and meta-analysis of 12 randomized controlled trials found "supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects." The review also indicates that "the effect of ALC in younger subjects was not more effective than placebo in improving these symptoms." indicating a need for more research explaining the age/effect relation

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8.3 Endogenous cannabinoids Cannabinoid receptor 1 (CB1) is predominantly distributed in the nerve cells of both the CNS and PNS and regulates both the sensory and affective components of pain, while cannabinoid receptor 2 (CB2) is expressed mainly on immune cells, including central glial cells and peripheral immune cells (152)