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Alternatively, administering megadoses of pyridoxine at 500 mg/kg or 1,000 mg/kg daily, which corresponds in humans to 83.3 mg/kg and 166.7 mg/kg, respectively [28], injected intraperitoneally into Wistar rats five days a week for 2 or 6 weeks, affected spermatogenesis and reduced the weights of reproductive organs

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Such brief investigations do not provide ample evidence to fully understand the ramifications of increased GH levels via ipamorelin therapy, despite the peptide's evident potency