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However, studies in rodents suggest that tonic firing releases dopamine in the nanomolar range while phasic firing increases the released dopamine concentrations up to micromolar levels (Matt and Gaskill, 2020)

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In vitro and in vivo animal studies have explored how peptide-based interventions can modulate these pathways, with research demonstrating peptide-mediated suppression of UV-induced MMP expression and reduction in oxidative stress markers in irradiated cell cultures