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The break is not required for safety or receptor resensitization, but it allows for reassessment and prevents indefinite use of a compound with limited long-term human data

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Gut-Brain Axis Modulation: 2025 microbiome studies (Gut Journal) indicate B12 enhances short-chain fatty acid production by 15-20% in the gut, improving vagal nerve signaling and reducing stress-related cortisol by 10-15%