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The FDA has classified BPC-157 as a substance with significant safety risks (Category 2, September 29, 2023) and its 2026 briefing notes adverse event reports involving compounded injections

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Plusieurs cas d' éruptions acnéiques ont été rapportés dans la littérature suite à la prise orale de cette molécule, pouvant s'expliquer par la dépendance à la vitamine B12 du métabolisme anaérobie de Cutibacterium acnes , la bactérie impliquée dans l'acné