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The exponential error model or additive error model was used for assessing the inter-study variability, which is shown in formulas (d–g): where η 1, i and η 2, i represent the variabilities of inter-study, which are added into E max or ET 50 when available and they are assumed to be distributed normally and the distribution characteristics are a mean of 0 and variance of ω 1, i 2 and ω 2, i 2 , respectively

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Specifically, KLOW adds one compound to the GLOW triple-blend: KPV, a tripeptide derived from the C-terminal of alpha-melanocyte-stimulating hormone that introduces melanocortin receptor-mediated anti-inflammatory signaling into the stack