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Within this context, the presence of excess iron, mainly in the form of intracellular hemosiderin and associated low molecular weight (LMWt) labile iron, can progressively cause molecular, cellular, and tissue damage, and a vicious circle leading to oxidative stress toxicity damage in cells (Figure 2) [57,65,66,67]

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Visualization of top 10 candidate MR proteins and expression of known target genes for a model (HCM-BROD-0003-C71) that does not match its tumor’s MR activity profile