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This principle is the fundamental reason why loading doses are necessary for drugs with very long half-lives such as for amiodarone with a t 1/2 of over 50 days

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Volume:90 Days - 6 Bottle

(38431210) Relative glutathione depletion may contribute: Glutathione deficiency up-regulates glutamylcysteine synthetase, which increases the level of glutamylcysteine