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His landmark essay thus established PD as a distinct neurological entity, creating a foundational understanding that catalyzed subsequent neuropathological research, notably the discovery of Lewy bodies and dopamine deficits pivotal to our current comprehension of PD [1,7]

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The mTG catalyzes under pH-controlled aqueous conditions (including physiological conditions) a transamidation reaction between a ‘reactive’ glutamine of a protein and a ‘reactive’ lysine residue whereas the latter can also be a simple, low molecular weight primary amine such as a 5-aminopentyl group