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2 and eTable 3), suggesting that the source of HC group, unevenly distributed age, and sex ratio were three confounding factors that may affect the meta-analysis outcome

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Insulin receptor substrate proteins, chiefly IRS-1, are recruited and phosphorylated, providing binding sites for the regulatory subunit of phosphoinositide 3-kinase and leading through PIP3 and PDK1 to Akt, and onward to mTOR complex 1, GSK-3 and the FoxO transcription factors