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MTT reagent, crystal violet, 4-hydroxytamoxifen (4HT), N-desmethyltamoxifen (NDMT), vitamin E (α-Tocopherol), TBHQ (tert-Butylhydroquinone), PMC (2,2,5,7,8-Pentamethyl-6-chromanol), DMSO, protease inhibitors cocktail, sodium orthovanadate and formic acid were from Sigma (Oakville, ON, Canada)