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These reactions become a significant source of OH• in the presence of oxidative stress conditions or when the concentration of free, unbounded transient ions rises, as in the case of hemodialysis

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The liver exhibited an increase in VD regulatory genes (VDBP/VD-25-hydroxylase/VDR) and the muscle showed an upregulation of glucose metabolism genes (VDR/PGC-1α/GLUT-4)