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The treatment was well tolerated, with no adverse events or clinically meaningful changes observed in vital signs, electrocardiograms, or laboratory biomarkers assessing cardiac, hepatic, renal, thyroid, or metabolic function

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A study of LGR-7, a primary receptor of RLX-2, has shown that RLX-2 suppressed collagen-I, PAI-1, and IL-8 expression in ESCs [82] and all these molecules have an important role in fibrosis formation [83, 84]