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Given that GSH levels are low in asthma, particularly in cases of severe disease, insufficient methionine intake or alterations of sulfur amino acid metabolism could be responsible

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51,52 Although our preclinical studies mostly employed male mice, this choice was made to minimize variability, particularly because MAOB is located on the X chromosome, making males a more straightforward model for assessing MAOB effects without the potential confound of X-inactivation