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Mechanistically, L2HG acts as a metabolic-epigenetic regulator that inhibits 2-oxoglutarate-dependent dioxygenases, induces histone hypermethylation, and remodels chromatin accessibility to activate an ATF3-dependent transcriptional program

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Megaloblastic anemia is caused by any disruption of this mechanism or a deficiency in vitamin B12 [19]

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