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Common Cagrilintide Side Effects Research with cagrilintide has identified several predictable effects related to its mechanism of action: Gastrointestinal Effects (Most Common): Nausea (reported in 40-60% of research subjects) Vomiting (typically mild and transient) Diarrhea or constipation Abdominal discomfort Reduced appetite (intended therapeutic effect) Other Observed Effects: Injection site reactions (redness, itching) Fatigue during initial weeks Headache (usually temporary) Dizziness (particularly with rapid dose escalation) The good news is that most cagrilintide side effects diminish significantly over time as the body adapts to amylin receptor activation [7]