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However, Sermorelin activates only the GHRH receptor pathway and produces a brief GH pulse (half-life of about 10 to 20 minutes (a peer-reviewed Advanced Drug Delivery Reviews paper identifying sermorelin as GRF 1-29 and reporting its short plasma half-life of about 10 to 20 minutes in humans)) that does not sustain the IGF-1 elevation many patients need for meaningful body composition and anti-aging results