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In addition, EGCG suppresses the oncogenic STAT3 pathway by blocking IL-6-induced phosphorylation, nuclear translocation, and transcription of survival genes such as Bcl-2 , Mcl-1 , and cyclin D1 , thereby complementing its mitochondrial actions at both organelle and nuclear levels (Yönden et al., 2023)

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Too often, local adverse effects are only discovered at the clinical trial stage or when a drug is already on the market